Built with the best in class.

Portal Innovations invests in biotech and medtech startups from seed to Series A. We work with life sciences founders in each of our ecosystems to help them grow by providing physical, human, and financial capital.


Boston

Targeting DNA repair deficiencies in tumors

Chicago

AI-enabled non-invasive cardiac monitoring

Chicago

Probiotic to support gut barrier function

Houston

Dual-payload antibody-drug conjugates

Chicago

3D printing therapeutics for organs

Chicago

Cell-penetrant, modular biologics

Houston

Drugging a novel target in the Wnt pathway

Houston

CAR-T cell therapies for hematological cancers

Atlanta

Peanut allergy immunotherapy

Houston

Oral drug to prevent diseases of aging

Chicago

Chemoproteomics drug discovery

Chicago

Non-invasive thermal sensors to monitor fluid flow

Boston

Screening platform and RNA logic gates

Atlanta

Electrical stimulation for pain relief

Chicago

CRISPR-based platform for cell therapy manufacturing

Boston

Oral therapies for obesity and rare disease

Boston

Mitochondrial drugs for Parkinson’s disease

Boston

Enabling oral biologics


Spark and LINK

Portal Innovations has two strategic investment vehicles to support member companies: Spark and LINK.

Spark investments are early-stage, strategic investments made by Portal in founders with breakthrough science and strong potential—often at the pre-seed stage. These investments aim to catalyze momentum.

LINK investments are in-kind investments that convert a portion of a company’s membership fees into equity, enabling access to Portal’s premium lab space, resources, and network. These investments are reserved for companies with compelling science and the potential for meaningful impact while helping them conserve cash and focus on growth.


Atlanta

Rapid optical antimicrobial susceptibility testing platform

Chicago
Chicago
Chicago
Chicago
Venture
Chicago

Inspired by Joseph Walder’s lifelong passion for scientific discovery, Walder’s support helps us provide capital, infrastructure, and expertise to high-potential startups developing breakthrough products to help patients.